Gregory Bisson

Gregory P. Bisson is a distinguished physician-scientist at the University of Pennsylvania's Perelman School of Medicine, where he serves as a faculty member in the Department of Medicine's Infectious Disease Division. His research focuses primarily on improving treatment outcomes for patients with HIV and tuberculosis, particularly in resource-limited settings. His groundbreaking work includes leading one of the first published studies examining the effects of antiretroviral therapy costs on patient outcomes in Africa. Dr. Bisson has received numerous prestigious grants, including a K23 Mentored Career Development Award, National Research Science Award, and multiple Research Project Grants. His significant contributions include demonstrating the limitations of WHO-advocated CD4 count monitoring and showing that adherence monitoring was more effective in resource-limited settings. As the first Penn researcher to establish formal research studies in Botswana, he helped create the research component of the Botswana-UPenn Partnership. His current work investigates early mortality in HIV patients after antiretroviral therapy initiation and explores novel host-directed therapies for drug-resistant TB. His research has led to important discoveries about TB treatment strategies, including findings that empiric TB treatment offers no advantage over isoniazid preventive therapy in certain populations.