Sleep: Neurobiology, Medicine, and Social Impact

This unit begins with a Course Overview video, followed by the first portion of the Neurobiology of Sleep and Wakefulness lecture. It covers defining behavioral states, historical overview of brain regions involved in sleep, and neurotransmitter systems related to wake and REM sleep.

This unit continues the lecture on the Neurobiology of Sleep and Wakefulness, focusing on additional neurotransmitter systems involved in wake, REM, and NREM sleep.

This unit covers mathematical modeling of sleep-wake regulation, including the Two Process Model, Sleep-Wake Flip-Flop Model, and other mechanistic models of sleep-wake regulation.

This unit covers the molecular biology and genetics of sleep, including gene expression during sleep and wakefulness, genetic modulation of synaptic plasticity, and genetic influences on human sleep phenotypes.

This unit provides an overview of sleep medicine, covering clinical approaches to sleep disorders, polysomnography, classification of sleep disorders, and a focus on obstructive sleep apnea.

This unit explores how disordered sleep and breathing can alter cardiovascular health, including the impact of sleep-disordered breathing on cardiovascular function and outcomes of CPAP therapy.

This unit explores the relationship between sleep and psychiatric disorders, covering sleep alterations associated with specific psychiatric disorders, including bipolar disorder, schizophrenia, anxiety disorders, and substance use disorders.

This unit covers the causes and consequences of insomnia, including the impacts of insomnia on daily life, factors contributing to insomnia, and the relationship between insomnia and hyperarousal.

This unit covers various treatments for insomnia, including both pharmacological and non-pharmacological approaches. It discusses different types of sleep medications, their potential for abuse, and cognitive-behavioral therapy for insomnia (CBT-I).

This unit explores the relationship between sleep and anesthesia, discussing shared phenotypes, mechanisms, and potential shared functions between sleep and anesthetic states.

This unit discusses the importance of sleep, circadian rhythms, changes in sleep patterns across the lifespan, and the concept of sleep hygiene. It emphasizes the role of circadian rhythms in sleep regulation and overall health.

This unit covers daytime sleepiness and sleep need, discussing how sleepiness is measured, the prevalence of sleepiness in society, and various causes of daytime sleepiness.