Modern Molecular Genetics: From Classical Studies to Today
Explore landmark experiments and discoveries that shaped our understanding of genes, DNA, and molecular biology.
Explore landmark experiments and discoveries that shaped our understanding of genes, DNA, and molecular biology.
This course delves into the foundational papers of molecular genetics, offering students a unique opportunity to study the original research that established key concepts in modern biology. Led by Professor Dominique Belin, the course covers seminal work on gene-enzyme relationships, DNA as genetic material, mutation origins, DNA structure, genetic code, gene regulation, and more. Students will read and analyze landmark papers by scientists like Beadle and Tatum, Avery, Watson and Crick, Benzer, Jacob and Monod, among others. The course not only provides historical context for major discoveries but also emphasizes the scientific process, experimental design, and the evolution of ideas in genetics and molecular biology.
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What you'll learn
Understand the historical context and significance of landmark papers in molecular genetics
Analyze experimental designs and methodologies used in foundational genetics research
Explore the development of key concepts such as the gene-enzyme relationship, DNA structure, and the genetic code
Examine the evolution of ideas about gene regulation, including the operon model
Study the contributions of bacterial and bacteriophage genetics to molecular biology
Understand the impact of technological advances on genetic research, such as DNA sequencing
Skills you'll gain
This course includes:
12.5 Hours PreRecorded video
12 quizzes
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FullTime access
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There are 12 modules in this course
This course provides an in-depth exploration of classical papers in molecular genetics, tracing the development of key concepts that form the foundation of modern biology. It begins with early work on gene-enzyme relationships and progresses through the discovery of DNA as the genetic material, the elucidation of DNA structure, and the deciphering of the genetic code. The course covers landmark experiments in bacterial genetics, including the work on mutation origins by Luria and Delbrück, and the groundbreaking studies on gene regulation in the lac and ara operons by Jacob, Monod, and others. Students will study Benzer's fine structure mapping of genes, the discovery of messenger RNA, and the development of DNA sequencing techniques. Throughout the course, emphasis is placed on understanding the experimental approaches, the interpretation of results, and how these findings contributed to the evolution of molecular biology. The historical context of each discovery is discussed, providing insight into the scientific process and the development of ideas over time.
Session 1
Module 1 · 2 Hours to complete
Session 2
Module 2 · 2 Hours to complete
Session 3
Module 3 · 2 Hours to complete
Session 4
Module 4 · 1 Hours to complete
Session 5
Module 5 · 2 Hours to complete
Session 6
Module 6 · 2 Hours to complete
Session 7
Module 7 · 2 Hours to complete
Session 8
Module 8 · 1 Hours to complete
Session 9
Module 9 · 2 Hours to complete
Session 10
Module 10 · 2 Hours to complete
Session 11
Module 11 · 2 Hours to complete
Session 12
Module 12 · 2 Hours to complete
Fee Structure
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Instructor
Professor at the University of Geneva
Dominique Belin is a professor at the University of Geneva, where he specializes in molecular biology. He studied chemistry and biology in Geneva and completed his PhD under Richard H. Epstein, focusing on bacteriophage T4. His doctoral research uncovered a temperature-sensitive mutant affecting the initiation codon of the rIIB gene. Following a postdoctoral fellowship at Rockefeller University, he investigated plasminogen activators and their role in fibrinolysis. Upon returning to Geneva, he collaborated with Jean-Dominique Vassalli on the fibrinolytic cascade, exploring the behavior of protease inhibitors from the SERPIN superfamily. His research interests include protein translocation mechanisms and microbial systems, particularly the SecYEG translocation machine. Notably, his work has contributed to understanding how certain signal sequences can affect protein targeting and translocation efficiency. Prof. Belin has also been involved in sequencing the phage T4 genome, revealing its capacity to encode numerous proteins with unclear functions. He teaches courses such as "Classical Papers in Molecular Genetics," contributing to the education of future scientists in this field.
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4.7 course rating
238 ratings
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