This course is part of CERTaIN: Mastering Comparative Effectiveness Research.
This comprehensive course equips participants with essential skills for critically evaluating scientific literature and conducting systematic reviews and meta-analyses in healthcare research. The curriculum covers the entire knowledge synthesis process, from literature search strategies using online academic databases to the interpretation and reporting of findings. Participants will learn methodologies for direct and indirect meta-analyses, approaches for evaluating non-randomized studies, and techniques for diagnostic test evaluation. The course also explores economic evaluations and decision analysis models that inform clinical practice. Through 11 focused lectures, students gain practical knowledge about the knowledge-to-action process, the benefits and limitations of systematic reviews, and various approaches to data synthesis. Specific topics include intervention review methodologies, heterogeneity assessment, evidence networks, meta-regression, meta-synthesis, and ROC curves for analyzing test performance. The program also covers clinical practice guideline development, cost-effectiveness analysis, and Markov modeling for outcomes research. Designed for anyone interested in comparative effectiveness research (CER) and patient-centered outcomes research (PCOR), this course provides a solid foundation for evidence-based decision making in healthcare. Supported by the Agency for Healthcare Research and Quality, it offers valuable insights for researchers, clinicians, and healthcare decision-makers.
Instructors:
English
English
What you'll learn
Conduct systematic literature searches using academic databases to locate published and unpublished materials
Perform critical appraisal of research studies using standardized methodologies
Synthesize evidence through meta-analysis techniques for both randomized and non-randomized studies
Interpret and report results from systematic reviews and meta-analyses
Evaluate diagnostic tests using measures of validity, likelihood ratios, and ROC curves
Understand the development process for clinical practice guidelines
Skills you'll gain
This course includes:
PreRecorded video
Graded assignments, exams
Access on Mobile, Tablet, Desktop
Limited Access access
Shareable certificate
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There are 11 modules in this course
This course provides a comprehensive introduction to knowledge synthesis methodologies and their application in clinical decision making. Beginning with an overview of systematic reviews, it explores the knowledge-to-action process and the steps involved in conducting evidence reviews. Students learn practical skills for searching and managing biomedical literature, including techniques for locating both published and unpublished materials in a systematic manner. The course delves into intervention review methodologies, covering study selection and appraisal, data collection and analysis, and reporting practices. Meta-analysis techniques are examined in depth, with separate modules on direct comparisons of clinical trials, indirect comparisons with evidence networks, and special considerations for non-randomized studies. Additional topics include diagnostic test evaluation (covering precision, accuracy, and ROC curves), qualitative meta-synthesis approaches, clinical practice guideline development and evaluation, economic evaluation methods (including cost-effectiveness analysis), and decision analysis modeling for outcomes research. Throughout the course, students gain practical skills for synthesizing evidence and applying it to healthcare decision making.
Overview of Systematic Reviews
Module 1
Finding and Managing the Evidence from the Biomedical Literature
Module 2
Intervention Reviews Methodology
Module 3
Meta-Analysis of Clinical Trials: Direct Comparisons
Module 4
Meta-Analysis of Non-Randomized Studies
Module 6
Diagnostic Test Evaluation
Module 7
Meta-Synthesis
Module 8
Clinical Practice Guidelines
Module 9
Economic Evaluation
Module 10
Decision Analysis for Outcomes Research
Module 11
Fee Structure
Individual course purchase is not available - to enroll in this course with a certificate, you need to purchase the complete Professional Certificate Course. For enrollment and detailed fee structure, visit the following: CERTaIN: Mastering Comparative Effectiveness Research
Payment options
Financial Aid
Instructors

5 Courses
Barnts Family Distinguished Professor at The University of Texas MD Anderson Cancer Center
Dr. Suarez-Almazor is Professor and Deputy Chair in the Department of General Internal Medicine at The University of Texas MD Anderson Cancer Center in Houston, TX. She is Head of the Section of Rheumatology and Clinical Immunology.

1 Course
Assistant Professor at The University of Texas MD Anderson Cancer Center
Dr. Lopez-Olivo is Assistant Professor at The University of Texas MD Anderson Cancer Center with expertise in pharmacology, epidemiology, and evidence-based medicine and its application to clinical decision-making evidence-based medicine
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