Cellular Design in Biological Engineering
Learn how to engineer living cells using fundamental design principles and explore emerging biohybrid technologies and applications.
Learn how to engineer living cells using fundamental design principles and explore emerging biohybrid technologies and applications.
This innovative course bridges engineering principles with cellular biology, teaching students to view cells as engineerable machines. The curriculum covers cellular architecture, gene expression, dynamics, and biohybrid devices. Students learn established and emerging design principles for cellular engineering, mathematical models for cell function, and applications in energy, water, food, and health sectors. The course culminates with exploration of synthetic life and ethical considerations.
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What you'll learn
Apply engineering principles to understand cellular function
Analyze cellular systems using mathematical models
Design and engineer cellular components and circuits
Understand biohybrid device development and integration
Evaluate applications in synthetic biology
Consider ethical implications of cellular engineering
Skills you'll gain
This course includes:
Live video
Graded assignments, exams
Access on Mobile, Tablet, Desktop
Limited Access access
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There are 6 modules in this course
This comprehensive course explores the intersection of engineering principles and cellular biology. The curriculum is structured across six modules, progressing from fundamental cellular concepts to advanced applications in biohybrid devices. Topics include cell architecture, gene expression circuits, cellular dynamics, and device integration. Special emphasis is placed on understanding cells as engineerable machines and their applications in solving global challenges in health, energy, and environmental sectors.
Introduction
Module 1 · 1 Weeks to complete
Cell Architecture
Module 2 · 1 Weeks to complete
Gene Expression & Circuits
Module 3 · 1 Weeks to complete
Cell Dynamics
Module 4 · 1 Weeks to complete
Cellular Devices
Module 5 · 1 Weeks to complete
The Future
Module 6 · 1 Weeks to complete
Instructors
Pioneering Biomedical Engineer Bridging Research Innovation and Educational Leadership
Dr. Jenna Rickus serves as Vice Provost for Teaching and Learning at Purdue University, where she holds professorships in Agricultural and Biological Engineering and the Weldon School of Biomedical Engineering, bringing a unique blend of research expertise and educational innovation to her roles. After earning dual BS degrees from Purdue in Agricultural & Biological Engineering and Biochemistry, followed by industry experience at Kraft Foods and a Ph.D. in Neuroscience and Neuroengineering from UCLA, she has established herself as a leading figure in biomedical engineering research and education. Her groundbreaking work spans engineered biomaterials for sensing and actuating living cells and tissues, with applications in brain cancer, type 1 diabetes, foodborne illness, and space biology, supported by prestigious funding from NIH, NSF, USDA, NASA, Army Research Office, and DARPA. As an educational innovator, she founded Purdue's international genetically engineered machine undergraduate research team and has transformed teaching approaches in biological engineering. Her contributions have earned her numerous accolades, including the ASEE Biomedical Engineering Teaching Award and induction into the Purdue Innovator's Hall of Fame, while her research has garnered over 1,700 citations, reflecting her significant impact on both the scientific community and educational landscape
Pioneering Biosensor Researcher Advancing Neural Monitoring Technology
James Nolan is an accomplished researcher in biological engineering at Purdue University, where he has made significant contributions to the development of advanced biosensor technologies. As an Outstanding Senior in Biological Engineering at Purdue, he has focused his research on creating lab-on-chip devices with multi-modal sensing capabilities for neurological disorders. His work includes developing flexible biosensor arrays for multianalyte measurements from human astrocytes and advancing electrochemical sensor technologies. Through his collaboration with Professor Rickus's lab, he has contributed to groundbreaking research in glutamate biosensors and real-time characterization of cellular uptake kinetics. His research has garnered significant attention with over 249 citations, particularly for his work on flexible glutamate biosensors and glucose monitoring systems. Beyond his research, he has served as a graduate teaching assistant managing over 2,200 students across 116 different programs. His master's thesis, "Towards Highly Sensitive Multi-analyte Micro-biosensor Arrays for In Vitro Sensing," demonstrates his expertise in developing sophisticated sensing technologies for biological applications.
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