Lead Selection & Optimization
Master drug discovery techniques focusing on identifying and optimizing lead compounds for clinical development through case studies and hands-on learning.
Master drug discovery techniques focusing on identifying and optimizing lead compounds for clinical development through case studies and hands-on learning.
This course cannot be purchased separately - to access the complete learning experience, graded assignments, and earn certificates, you'll need to enroll in the full Drug Hunting: The Science of Making New Medicines Specialization program. You can audit this specific course for free to explore the content, which includes access to course materials and lectures. This allows you to learn at your own pace without any financial commitment.
Instructors:
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What you'll learn
Identify optimal characteristics for effective small molecule therapeutics
Apply principles of pharmacophore definition and optimization
Evaluate lead compounds using various screening assays
Analyze structure-activity relationships in drug development
Optimize ADME properties for clinical candidates
Skills you'll gain
This course includes:
1.3 Hours PreRecorded video
12 assignments
Access on Mobile, Tablet, Desktop
FullTime access
Shareable certificate
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There are 3 modules in this course
This comprehensive course explores the crucial stages of drug discovery, focusing on lead compound identification and optimization. Using an antimalarial therapy case study, students learn about screening assays, selection criteria for leads, and structure-activity relationships. The curriculum covers pharmacophore optimization, ADME properties, and both phenotypic and target-based approaches to drug discovery. Topics include potency assessment, efficacy evaluation, and the transformation of promising compounds into suitable clinical candidates.
Lead Selection & Optimization, part 1
Module 1 · 1 Hours to complete
Lead Selection & Optimization, part 2
Module 2 · 4 Hours to complete
Lead Selection & Optimization, part 3
Module 3 · 2 Hours to complete
Fee Structure
Instructors
7 Courses
Medicinal Chemistry Expert and Educator at Davidson College
Dr. Erland Stevens is a distinguished faculty member in the Chemistry department at Davidson College, bringing a wealth of experience in medicinal chemistry and drug discovery to his role. After earning his Ph.D. from the University of Michigan at Ann Arbor in 1997, specializing in nitrogen heterocycles under Will Pearson, Stevens pursued postdoctoral studies at The Scripps Research Institute with K. Barry Sharpless. Joining Davidson College in 1998, he has since become a cornerstone of the chemistry program, regularly teaching medicinal chemistry to junior and senior undergraduates. Stevens' expertise extends beyond academia, as evidenced by his involvement in the continuing education program at GlaxoSmithKline's Research Triangle Park site in 2006 and 2007. His contributions to the field include authoring the textbook "Medicinal Chemistry: The Modern Drug Discovery Process," published by Pearson Education, which has likely become a valuable resource for students and professionals in the field. Stevens' research focuses on the synthesis and activity of antiviral nucleoside analogues, demonstrating his ongoing commitment to advancing pharmaceutical science. His career exemplifies the integration of academic research, industry relevance, and dedicated teaching in the field of medicinal chemistry.
Director of Preclinical Safety at Novartis
Dr. Alan P. Brown is a Director in Preclinical Safety at Novartis, where he supports therapeutic programs focused on cardiovascular disease. His responsibilities include evaluating compounds for in-licensing and acquisitions, co-chairing a liver safety advisory team, and conducting educational workshops for colleagues at Novartis. Dr. Brown holds a Bachelor of Science in microbiology from the University of Michigan and a Ph.D. in pharmacology and toxicology from the University of Arizona. He completed postdoctoral research at Michigan State University and is a Diplomate of the American Board of Toxicology. With extensive experience in the pharmaceutical industry, he plays a vital role in ensuring the safety and efficacy of new therapeutic compounds.
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Frequently asked questions
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