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Biopharmaceutical Manufacturing Essentials
Master biologic drug development: learn cell culture, protein purification, quality control, and regulatory compliance in pharmaceutical manufacturing.
Master biologic drug development: learn cell culture, protein purification, quality control, and regulatory compliance in pharmaceutical manufacturing.
Dive into the fascinating world of biopharmaceutical manufacturing with this comprehensive course from MITx. Over four weeks, you'll explore how cells are engineered and cultivated to produce target biologics, and learn the intricate processes involved in purifying these life-saving medicines. This course bridges theory and practice by showcasing real biomanufacturing equipment in action and featuring expert insights on industry challenges. Ideal for those with a basic understanding of organic chemistry, calculus, and molecular biology, this course offers a unique opportunity to understand the cutting-edge field of protein therapeutics production.
Instructors:
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What you'll learn
Understand the principles of engineering cells for biologic production
Explore techniques for cultivating cells to produce target biologics
Learn methods for purifying biopharmaceutical products
Analyze the historical development of biopharmaceutical manufacturing
Examine real-world biomanufacturing equipment and processes
Understand the challenges and solutions in large-scale biologic production
Skills you'll gain
This course includes:
Live video
Graded assignments, exams
Access on Mobile, Tablet, Desktop
Limited Access access
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Top companies offer this course to their employees
Top companies provide this course to enhance their employees' skills, ensuring they excel in handling complex projects and drive organizational success.
Module Description
This course provides a comprehensive introduction to the principles of biopharmaceutical manufacturing, focusing on the production of protein therapeutics. Students will learn how cells are engineered and utilized as factories for producing biologic drugs that can treat previously untreatable diseases. The curriculum covers the entire biomanufacturing process, from cell engineering and cultivation to product purification. By connecting engineering fundamentals with real-world applications, the course offers insights into actual biomanufacturing equipment and processes. Participants will also explore the historical context of these technological developments, gaining a deeper understanding of how the field has evolved. This course is designed to provide a solid foundation in biopharmaceutical manufacturing principles, preparing students for further studies or careers in this rapidly growing field.
Fee Structure
Instructors
Pioneering Chemical Engineer Advancing Biomedical Research and Therapeutic Development
J. Christopher Love serves as the Raymond A. (1921) and Helen E. St. Laurent Professor of Chemical Engineering at MIT's Koch Institute for Integrative Cancer Research. His distinguished career began with a B.S. in Chemistry from the University of Virginia and a Ph.D. in Physical Chemistry from Harvard University under George Whitesides. After completing postdoctoral research in immunology at Harvard Medical School with Hidde Ploegh and the Immune Disease Institute, Love has established himself as a leading researcher combining chemical engineering, interfacial chemistry, and materials science to develop innovative micro- and nanotechnologies. His laboratory focuses on advancing therapeutic discovery, particularly in areas such as cancer, HIV/AIDS, multiple sclerosis, Type 1 diabetes, and food allergies. Love has garnered numerous prestigious accolades, including the W.M. Keck Distinguished Young Scholar for Medical Research, Dana Scholar for Human Immunology, and was named one of Popular Science's Brilliant 10. He has co-founded several biotechnology companies, including OneCyte Biotechnologies, HoneyComb Biotechnologies, and Sunflower Therapeutics, while also serving as a scientific advisor to companies like Repligen and Alloy Therapeutics. His research has resulted in over 100 manuscripts and multiple patents in single-cell analysis and biomanufacturing, demonstrating his significant impact on the field.
Distinguished Microbiologist and Metabolic Engineering Pioneer
Anthony J. Sinskey has established himself as a prominent figure in microbiology and metabolic engineering at MIT since 1968, where he serves as Professor of Microbiology in the Department of Biology and Professor of Health Sciences and Technology in the Harvard-MIT Health Sciences and Technology Program Engineering Systems Division. His educational journey began with a B.S. in Food Science from the University of Illinois, Urbana-Champaign, followed by an ScD from MIT in 1966. As a leading researcher, Sinskey's work focuses on interdisciplinary approaches to metabolic engineering, investigating fundamental physiology, biochemistry, and molecular genetics of important organisms. His research encompasses diverse areas, including amino acid metabolism in Corynebacterium glutamicum, bioremediation processes in Rhodococcus, and biopolymer synthesis in Gram-negative bacteria. Beyond his academic contributions, Sinskey serves as the Faculty Director of the Center for Biomedical Innovation and has received notable recognition, including the 2015 J-WAFS Solutions Grant for his innovative work on nanosensor platforms for monitoring food and water-borne contaminants. He has also co-founded biotechnology companies, including Metabolix, and serves on the board of directors of Tepha, Inc., demonstrating his significant impact on both academic research and industrial applications.
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Frequently asked questions
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