A comprehensive overview of techniques and approaches for evaluating drug candidates' biological effectiveness and cellular interactions.
A comprehensive overview of techniques and approaches for evaluating drug candidates' biological effectiveness and cellular interactions.
Dive into the world of drug discovery with this comprehensive course on measuring pharmacodynamics. From ligand binding to clinical outcomes, you'll explore various methods used to assess biological activity throughout the drug development process. Covering topics such as target-based drug discovery, biochemical and cellular assays, and dose-response curves, this course provides a solid foundation in the critical aspects of drug activity measurement. Designed for students with a basic understanding of proteins and biological pathways, the course offers a flexible learning experience with 15 modules spread over three weeks. Whether you're a aspiring pharmacologist or a professional looking to enhance your knowledge, this course will equip you with valuable insights into the intricate process of drug discovery and development.
Instructors:
English
English
What you'll learn
Understand the concept of target-based drug discovery and its role in altering biological pathways
Identify common types of biological molecules that serve as drug targets, focusing on enzymes and receptors
Analyze different outcomes of drug-target interactions, including inhibitors, agonists, and antagonists
Explore biochemical and cellular methods for measuring drug-target binding
Interpret dose-response curves and their significance in drug development
Evaluate types of outcomes used to determine the success of clinical trials
Skills you'll gain
This course includes:
PreRecorded video
Graded assignments, exams
Access on Mobile, Tablet, Desktop
Limited Access access
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There are 3 modules in this course
This course delves into the intricate world of measuring biological activity in drug discovery and development. Students will explore various methods used to assess drug activity, from molecular interactions to clinical outcomes. The curriculum is structured into three main sections: understanding drug targets and their interactions, exploring biochemical and cellular methods for measuring drug-target binding, and analyzing in vivo studies and dose-response curves. Key topics include target-based drug discovery, types of biological molecules serving as drug targets, outcomes of drug-target interactions, assay types, biomarkers, and the interpretation of dose-response curves. The course emphasizes the critical role of robust and informative measurement methods in accelerating the drug discovery and development process. Through a combination of instructional videos, readings, and assessment activities, students will gain a comprehensive understanding of pharmacodynamics and its application in pharmaceutical research.
Pathways, Targets, and Responses
Module 1
Types of Assays and Potency Measurements
Module 2
In Vivo Studies and Drug Discovery Applications
Module 3
Fee Structure
Instructor

7 Courses
Medicinal Chemistry Expert and Educator at Davidson College
Dr. Erland Stevens is a distinguished faculty member in the Chemistry department at Davidson College, bringing a wealth of experience in medicinal chemistry and drug discovery to his role. After earning his Ph.D. from the University of Michigan at Ann Arbor in 1997, specializing in nitrogen heterocycles under Will Pearson, Stevens pursued postdoctoral studies at The Scripps Research Institute with K. Barry Sharpless. Joining Davidson College in 1998, he has since become a cornerstone of the chemistry program, regularly teaching medicinal chemistry to junior and senior undergraduates. Stevens' expertise extends beyond academia, as evidenced by his involvement in the continuing education program at GlaxoSmithKline's Research Triangle Park site in 2006 and 2007. His contributions to the field include authoring the textbook "Medicinal Chemistry: The Modern Drug Discovery Process," published by Pearson Education, which has likely become a valuable resource for students and professionals in the field. Stevens' research focuses on the synthesis and activity of antiviral nucleoside analogues, demonstrating his ongoing commitment to advancing pharmaceutical science. His career exemplifies the integration of academic research, industry relevance, and dedicated teaching in the field of medicinal chemistry.
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