Getting started in cryo-EM
Learn the fundamentals of cryo-electron microscopy, from microscope operation to image processing, for biological structure analysis.
Learn the fundamentals of cryo-electron microscopy, from microscope operation to image processing, for biological structure analysis.
This comprehensive course introduces the principles and practices of cryo-electron microscopy (cryo-EM). Students learn about electron microscope anatomy, Fourier transforms, image formation, sample preparation, and data collection strategies. The curriculum covers all three main cryo-EM modalities: tomography, single particle analysis, and 2-D crystallography. Through detailed lectures and concept checks, participants gain practical understanding of this powerful structural biology technique.
4.9
(270 ratings)
23,492 already enrolled
Instructors:
English
پښتو, বাংলা, اردو, 2 more
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What you'll learn
Master electron microscope operation
Understand image formation principles
Learn sample preparation techniques
Analyze cryo-EM data effectively
Perform 3D reconstructions
Apply tomography methods
Skills you'll gain
This course includes:
847 Minutes PreRecorded video
8 modules
Access on Mobile, Tablet, Desktop
Batch access
Shareable certificate
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There are 8 modules in this course
This course provides a thorough introduction to cryo-electron microscopy through eight comprehensive modules. The curriculum progresses from basic microscope operation to advanced imaging techniques and data processing. Students learn theoretical concepts and practical applications, with emphasis on understanding fundamental principles rather than mathematical details.
Welcome
Module 1 · 49 Minutes to complete
Currents, Coils, Knobs and Names: Basic anatomy of the electron microscope
Module 2 · 2 Hours to complete
Fourier Transforms and Reciprocal Space for Beginners
Module 3 · 3 Hours to complete
Image Formation
Module 4 · 3 Hours to complete
Fundamental Challenges in Biological EM
Module 5 · 2 Hours to complete
Single Particle Analysis
Module 6 · 3 Hours to complete
Tomography
Module 7 · 3 Hours to complete
2-D Crystallography
Module 8 · 1 Hours to complete
Fee Structure
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Instructor
eading Structural Biologist at Caltech
Grant J. Jensen is a Professor of Biophysics and Biology at the California Institute of Technology (Caltech) and an Investigator at the Howard Hughes Medical Institute. A leading figure in structural biology, Jensen is at the forefront of advancing the field of electron cryotomography (ECT), an emerging microscope technology that enables the visualization of biological structures at the molecular level.
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4.9 course rating
270 ratings
Frequently asked questions
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